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When GLP-1 binds to GLP-1R on the surface of -cells, cAMP-dependent PKA is activated and subsequently activates the downstream signal PI3K, which inhibits apoptosis in islet -cells by blocking the expression of the pro-apoptotic protein Bax (Li et al., 2021) (Figure 4)

3, Supplementary Table S3)

Ultimately, drought results in limited growth and developmental processes and lower final crop yield (Pinheiro and Chaves 2010)

Zou K, Sun P, Huang H, Zhuo H, Qie R, Xie Y, Luo J, Li N, Li J, He J, et al

These mechanisms operate similarly regardless of a patient's baseline weight classification, though individual response varies based on metabolic factors and genetic predisposition

p = 0.04) (Table 3)