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For post-surgical repair methods, inclusion of a drug compound, particularly anticancer drugs such as paclitaxel, is also common

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Evidence Tier Framework Tier 1 FDA-approved therapy large randomized trials Tier 2 human trials demonstrating biological effect Tier 3 small human studies or limited clinical data Tier 4 animal models or anecdotal reports Stacking should generally involve: at least one Tier 1 therapy no more than one Tier 3 compound Stacks composed entirely of Tier 34 compounds should not be considered clinical protocols

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Areas of laboratory study include: Receptor-ligand binding affinity and kinetics