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Immunofluorescence Paraffin-embedded tissue samples were taken to prepare white slices (polylysine slides were used to prevent tissue detachment)

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Taken together, substratification of AF phenotypes may allow the combination of different mechanism-specific drugs (direct anti-arrhythmic atrial-selective channel-modifying drugs as well as modifiers of remodelling processes, inflammation etc.) and interventional therapies guided by the disease subtypes [130]