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The Journal of general physiology.139(6)

D.Duran-PradoM.LuqueR

Topiramate, an anticonvulsant originally approved for seizure management and migraine prevention, is sometimes prescribed off-label at lower doses (25200 mg daily) to suppress appetite and promote modest weight loss

For this reason, multiple surrogate matrices were investigated and 100 g/mL of bovine serum albumin (BSA) in water was found to be the best surrogate matrix