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67 This leads to elevated glycoursodexoycholic acid levels, which in turn depress the activity of intestinal farnesoid X receptor culminating in improved glucose tolerance

As the GP activity was previously studied only in tissues such as rat liver and placenta without optimization of substrata conditions [7], the selection of blood as the target compartment to study the effect of systemic peroxide levels has the advantage of investigating the compartment subjected to all the comprehensive effects of peroxide systemic accumulation