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doi: 10.3390/cells14171335 39 WangZWanYMengXZhangXYaoMMiuWet al

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Furthermore, the therapeutic application of ursolic acid is significantly hindered by its poor solubility in aqueous medium and limited bioavailability in vivo

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Indeed, the history of anti-obesity medications has been marked by several failures due to serious adverse events, such as suicidality, observed only after their usage had become extensive 221,234 a well-known example being the one that led to the withdrawal of the endocannabinoid inverse agonist, rimonabant 235