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This effect is most pronounced early in treatment and may attenuate over time with long-acting formulations

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Eli Lilly, the manufacturer of the injectable weight-loss medication Zepbound, has its own oral GLP-1 drug in the pipeline, orforglipron, which is being investigated as a treatment for both type 2 diabetes and obesity

2 The addition of semaglutide to the Food and Drug Administration (FDA) shortage list from 2022 to February 2025, and tirzepatide to the same list from 2022 to December 2024, gave compounding pharmacies permission by the FDA to produce exact duplicates to ensure continuity of treatment until production met demand