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All available safety data including information on skin sensitivity derives from clinical trial publications, conference presentations, and investigator reports, rather than from a formally approved regulatory dossier

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Warning Text (paraphrased from FDA prescribing information): WARNING: RISK OF THYROID C-CELL TUMORS In rodent studies, semaglutide and tirzepatide caused thyroid C-cell tumors

For example, in a patient with intentional overdose who is also on a GLP-1 agonist, the time to peak concentration of co-ingested agents may be prolonged, complicating risk assessment, decontamination decisions, and timing of antidotal therapies

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