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Cagrilintide is a long-acting amylin analogue, whilst retatrutide is a novel triple receptor agonist targeting GLP-1, GIP, and glucagon pathways

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Serious but rare adverse effects include pancreatitis, gallbladder disease, acute kidney injury (usually secondary to dehydration from gastrointestinal symptoms), and hypoglycemia when combined with insulin or sulfonylureas

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