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Children who ingest a single dose greater than 250 mg/kg have significant risk of developing acetaminophen-induced hepatotoxicity

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[10] [11] Compliance with the updated labeling regulations was required by 1 January 2020 for manufacturers with US$10 million or more in annual food sales, and by 1 January 2021 for manufacturers with lower volume food sales

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It may also play a role in preventing tissue breakdown, which can occur when restricted blood flow causes tissue damage