In familial PD patients with SNCA multiplications, high levels of -synuclein in blood were reported (Miller et al., 2004)
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Combination in patients with Type 2 Diabetes Mellitus and Moderate Renal Impairment with Metformin alone, Sulfonylurea alone, Basal Insulin alone or Metformin in Combination with either Sulfonylurea or Basal Insulin In a 26-week, double-blind trial (Trial 5, NCT02827708), 324 adult patients with moderate renal impairment (eGFRCKD-EPI 30-59 mL/min/1.73 m2) were randomized to RYBELSUS 14 mg or placebo once daily
Lancet 2019;394:12130.PubMed 2
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Similar patterns of cellular damage are observed in both metabolic disorders and PD, including mitochondrial dysfunction, impaired autophagy, oxidative stress, endoplasmic reticulum stress, and gut microbiota alterations