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Patients should attend scheduled visits for blood pressure checks, metabolic panel assessments (including renal function and electrolytes), and evaluation of diabetes control through hemoglobin A1c testing

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Semaglutide, originally developed for diabetes management, showed significant weight loss results in both clinical trials and real-world settings, which attracted widespread adoption

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Diabetes is characterized by chronic systemic hyperglycemia, which activates several secondary metabolic pathwayssuch as the polyol pathway, accumulation of AGE products, and protein kinase C (PKC) activationthat contribute to retinal and systemic vascular damage [67]

Hyperkeratotic lesions being treated with fluorouracil should be covered with an occlusive dressing, but this is not necessary on thin flat lesions on facial skin