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This disrupts the balance between bone resorption and formation, leading to increased bone resorption and reduced bone density

The highest monotherapy dose studied is 4.5 mg per week (Lancet 2021 Phase 2)

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doi: 10.1038/nm.2885 168 Witko-SarsatVPederzoli-RibeilMHirschESozzaniSCassatellaMA

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However, common adverse events such as upper respiratory tract infections, diarrhea and nausea were noted to be more common in the brodalumab-treated groups