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Importantly, neuroinflammation-associated gene expression signatures are enriched for AD genetic risk loci and recapitulate transcriptional changes in human AD hippocampus, and these signatures are ameliorated by semaglutide treatment

HEK293T cells were cultured in Dulbeccos modified Eagles medium (DMEM) (Invitrogen, Carlsbad, CA, #12800082) with 10% Fetal Bovine Serum (FBS) (Invitrogen, Carlsbad, CA, #10099-141) supplemented with 100 units/mL penicillin and streptomycin (Invitrogen, Carlsbad, CA, #15140122)

Bupropion does not

These small molecules delivered substantial body weight loss (efficacy)

Around 12% of U.S

Drinking more water and eating fibre can help keep things moving