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Abstract Purpose of Review Glucagon-like peptide- 1 receptor agonists (GLP- 1 RA) are a rapidly expanding class of medications used to treat many chronic diseases

The split dosing approach , where the weekly dose is divided into two smaller injections, may reduce peak-related side effects for some patients

Many patients find symptom relief by pausing dose escalation temporarily, allowing the body to adapt before advancing to the next dose level

This risk appears to be higher in people with a history of pancreatitis or risk factors for it, such as heavy alcohol use or gallstones

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Metabolic diseases are associated with altered microbial functionality, composition, and diversity 250,251,252