From around age 30, we begin to lose muscle mass (sarcopenia), in part due to anabolic resistance
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Notably, recent research suggests this relationship is bi-directional: aging causes circadian/sleep disruption, and conversely, circadian disruption can accelerate aspects of aging ( Given these insights, there is intense interest in identifying interventions that can stabilize or strengthen circadian rhythms in older people
Temperature extremes can affect medication stability
Recent evidence suggests that this temporal regulation involves not only the hypothalamicpituitaryadrenal axis but also mesolimbic reward pathways, where circadian fluctuations in monoaminergic neurotransmission (particularly dopamine and serotonin) influence endocrine responses to environmental cues (116, 117)
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