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Nishida Y, MD, PhD, Ishizawa J, MD, PhD, Ayoub E, PhD, Patsilevas T, BS, Ostermann L, Montoya RH, BS, Muftuoglu M, MD, Ruvolo V, MS, Mak PY, Tao W, Carter BZ, PhD, Kojima K, MD, PhD, Daver N, MD, Lesegretain A, Seki T, PhD, Shacham S, PhD, MBA, Konopleva M, MD, PhD, Andreeff M , MD, PhD

Consistent with this, C-terminally truncated Syn variants in our study display progressively stronger high-affinity, nonfunctional interactions with Syn WT as truncation length increases, highlighting their reactive nature

But this is an off-label use that requires close monitoring

There is also a role for a pacemaker or implantable defibrillator (ICD)

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The data in Table 1 reflect the exposure of 304 patients with type 1 diabetes to TOUJEO with mean exposure duration of 23 weeks