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And as it turns out, both compounds are essential for fighting against cellular senescence

As adult neurogenesis is negatively correlated with stress and depression (Zhao et al., 2008) and major depression correlates with increased DNA methylation in the cortex (Veldic et al., 2005), this raises an intriguing possibility: could the depression-linked decrease in adult neurogenesis be a consequence of the increased methylation of NeuroD1 promoter in developing neurons

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Last Updated: November 20th, 2025