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Cell-mediated immunity plays a central role, with nave CD4 + T cells differentiating into effector subsets upon antigen recognition: Th1 cells secrete IFN-, IL-2, and TNF-, inducing MHC class II expression and promoting Fas-mediated apoptosis of thyrocytes
Three years later, that nonsense was incorporated into the 2019 re-definition of Stage B2 of MVD in the ACVIM's 2019 Consensus Statement
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Furthermore, replacing ZZ1s sulfinic acid with a negatively charged carboxylic acid group but not any of the related uncharged moieties tested partially supported BRD4 BD1 ubiquitylation in biochemical assays (Extended Data Fig