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At very low bioavailability, GI effects may be reduced simply because the peptide is not reaching effective concentrations anywhere in the body, including the brain

[5] Patients prescribed GLP-1 agonists often have type 2 diabetes or obesity, conditions independently associated with increased rates of osteoarthritis and other musculoskeletal disorders

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If xylitol gum was sufficient initially but dryness is worsening at higher doses, layer in a Biotene gel at night

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Insurance coverage for GLP-1 medications varies widely by plan, and some GLP-1 medications may not be covered by insurance