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Deficiencies in this pathway are studied in models of hepatic steatosis

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115 , 117 , 118 , 119 Outcomes following longterm exposure of setmelanotide were assessed in 2 patients with POMC deficiency who participated in a Phase 2, openlabel pilot study, followed by an openlabel extension study, with each receiving setmelanotide daily for a range of 6.87.2 years

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