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[DOI] [PubMed] [Google Scholar] 47.DeVan A.E., Eskurza I., Pierce G.L., Walker A.E., Jablonski K.L., Kaplon R.E., Seals D.R

This seemingly simple structural change produces approximately a 10-fold increase in potency compared to full-length IGF-1 in stimulating anabolic processes including protein synthesis, muscle hypertrophy, and cellular proliferation

Their ability to modulate insulin secretion, glucose regulation, and energy balance has significant therapeutic implications, especially for conditions like congenital hyperinsulinism and obesity

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