As MCs reside in tissues whereas basophils mainly circulate in blood, MC-derived histamine may play a role in coordinating neutrophil infiltration and exacerbating colitis
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A third incretin-based approach is tirzepatide, a dual agonist of GLP-1R and glucose-dependent insulinotropic polypeptide receptor (GIPR), which achieves greater HbA1c reduction and weight loss compared with GLP-1RAs alone
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12 (Table 2)