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This practical limitation is in stark contrast to the potential scale of excipient combinations, which can readily exceed 10 5 possibilities when considering the number of FDA-listed inactive ingredients (Pottel et al., 2020)

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The subsequent production of inflammatory cytokines, such as IL-1, IL-6, and TNF-, by these nociceptive free endings elicit spontaneous, repetitive action potentials in sensory afferents

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