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Many trial participants described the experience not as feeling hungry but resisting food, but rather as genuine disinterest in eating

As your treatment progresses, your healthcare provider will closely monitor your response to the medication and gradually increase the dose every four weeks, based on your tolerance and weight loss progress

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Your provider may initiate retatrutide at the lowest available investigational dose, monitor your response (body weight, appetite, blood sugar, side-effects), then decide on dose escalation (dose escalation) as tolerated similar in principle to how tirzepatide is titrated but potentially with more caution

They work by mimicking a natural hormone in your body