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Common side effects relating to sitagliptin include: Infections of the upper respiratory tract Headaches More infrequently, Sitagliptin is associated with abdominal pain, nausea and diarrhoea

doi: 10.1111/j.1749-6632.2009.04799.x 95 ArnettSVAllevaLMKorossy-HorwoodRClarkIA

In endothelial progenitor cells (EPC) derived from human peripheral blood mononuclear cells, high glucose conditions downregulate GLP-1-R and sirtuin 1 ( SIRT1 ) expression, leading to impaired cell functions and increased apoptosis via elevated acetylated p53 levels

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