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doi: 10.1176/appi.ajp.159.6.1055 175 FountaineRJTaylorAEMancusoJPGreenwayFLByerleyLOSmithSRet al

The precise strategy is described in the 'Materials and methods' of that study

Topical Glutathione If using glutathione-containing creams or serums (sometimes offered for localized hyperpigmentation or melasma), the timeline could be similar to other lightening topicals, expect at least 810 weeks of daily application to see improvement

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Furthermore , excessive shaking can lead to aggregation or denaturation