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There are no published guidelines regarding the optimal management of pasireotide-induced hyperglycemia in patients with acromegaly 22 , but the most currently recommended treatment is metformin, followed by dipeptidyl peptidase-4 (DPP-4) inhibitors, GLP-1 analogs, and then insulin 22,23,24

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Correction Perhaps the most crucial finding from the clinical research is the importance of timing interventions appropriately

Gradual discontinuation may reduce rebound effects compared to abrupt cessation

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Nutritional priorities to support GLP -1 therapy for obesity: A joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society