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Since this manuscript was written, the following authors have changed affiliation: Sharmistha Roy Chowdhury is now affiliated with the University Hospital of Wales, Cardiff and Vale UHB, Cardiff, United Kingdom

However, small donor sample sizes limit generalizability, as they may not capture donor-dependent shifts or reflect broader diversity in age, diet, or health

Clinical trials show patients who took Wegovy 2.4 mg weekly lost an average of around 15% of their body weight after 68 weeks

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1 Effectiveness Semaglutide has been evaluated as a single treatment and as additional treatment for patients already being treated with metformin, a sulfonylurea, or long-acting insulin in seven clinical trials enrolling more than 8,400 patients

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