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After treatment, patients are free to leave and resume normal activities immediately
This stall happens because the body adapts to the medication's appetite-suppressing effects, a phenomenon called tachyphylaxis
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10.1016/j.freeradbiomed.2009.05.026 27 CaiZ.YanL
In cisplatin-induced renal injury, MicroRNA-483-5p can induce the expression of GPX3 to weaken the oxidative stress response, thereby playing a protective role in renal injury (Xia et al., 2022)
This dual mechanism, which combines metabolic rebalancing through GLP-1RAs and direct neuroprotection mediated by brain-derived neurotrophic factor (BDNF), delayed neurodegeneration and suggests a viable strategy for long-term disease modification
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