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During oxidative phosphorylation, a small fraction of electrons leaks from Complexes I and III of the electron-transport chain, reducing molecular oxygen to superoxide (O)

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On the basis of this association, Fine et al 88 proposed in 2000 that chronic hypoxia is the final common pathway that leads to the development of end-stage renal failure

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Clinical and preclinical studies suggest that VNS can reduce neuroinflammation and protect against cognitive decline in various injury models, including those involving I/R

Friederich et al., 2009) or upon exposure to pharmacological drugs (Scatena et al., 2010) or ionizing radiation (Azzam et al., 2012)