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Acknowledgements The authors acknowledge the Australian Research Council (ARC) Centre of Excellence for Innovations in Peptide and Protein Science (CE200100012), the ARC Future Fellowship Scheme (FT240100010 to L.R.M.) and the Snow Medical Research Foundation (SMRF2023-158 to L.R.M.) for the funding

Clinical trials show patients on tirzepatide experience a 2030% reduction in food intake within the first four weeks, not through willpower alone but through genuine neurochemical shifts in hunger and reward pathways

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ChemBioChem 10 , 19881992 (2009)

This breakthrough drug has transformed many peoples weight loss experiences by giving them a safe and reliable way to lose unwanted pounds

Stapled peptides have been investigated for their potential as cancer inhibitors, exemplified by their application in the PPI between the tumor suppressor p53 and its negative regulator MDM2 and MDMX