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Therefore, the level of evidence is considered preliminary

J Clin Epidemiol

2009 RCT documented improvements in mottled hyperpigmentation alongside fine-wrinkle reduction in photoaged skin 10

Hierarchy of Evidence: Level D (Pre-clinical animal models)

Without long-term safety data, its impossible to fully assess risks or unintended consequences over months or years

[2] The result is vasoconstriction and increased systemic vascular resistance, which can be therapeutically useful in conditions like vasoplegic shock where pathological vasodilation has caused life-threatening hypotension