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However, their therapeutic outcomes are limited because of drug resistance due to the intracellular inactivation effect ( 2 complex with platinum drugs

Pol Arch Intern Med 133(78):16527 Petkovic-Dabic J et al (2025) Effects of semaglutide treatment on psoriatic lesions in obese patients with type 2 diabetes mellitus: an open-label, randomized clinical trial

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they use IGF-1 LR3 when targeting IGF-1 receptor effects in specific tissues without the upstream GH pathway