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The February 2026 TRIUMPH-4 readout showed 32.3 kg weight loss and 75.8% knee pain reduction at the 12 mg dose at 68 weeks
Phase 3 trials are currently ongoing (see ClinicalTrials.gov for the retatrutide Phase 3 programme), and these larger studies will provide more robust data on the long-term safety and tolerability of retatrutide across more diverse populations
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What feels like sudden failure is typically the natural plateau phase that occurs between weeks 40 and 48 for most users
The smaller final step from 8mg to 12mg (a 50% increase rather than a 100% doubling) reflects the finding that GI tolerability improves at higher doses once the body has already adapted to substantial receptor activation
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