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GLP-1s account for 23% of first line diabetes therapy in 2025 up from 3% in 2021 Since 2019, the American Diabetes Association (ADA) has revised its Standards of Care each year to expand the role of GLP-1 receptor agonists and SGLT2 inhibitors as first-line treatments for T2D 2

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Recent studies have shown that GIP can improve glycemic control in patients with T2DM [39,40] and have revived studies on the development of novel antagonists [41,42]

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Conclusion This meta-analysis clearly demonstrated that semaglutide reduces MACEs primarily by a reduction in CV-related deaths