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Results showed: Significant increase in skin density and thickness Measurable reduction in fine line depth (up to 35% in some cohorts) Improved skin laxity and elasticity scores Enhanced skin moisture retention These effects are largely attributed to GHK-Cus ability to stimulate fibroblast activity the cells responsible for producing collagen type I and III, elastin, and hyaluronic acid

10.1016/s0928-4257(97)89474-0 120 SikiricP.SeiwerthS.GrabarevicZ.RucmanR.PetekM.JagicV.et al (1997a)

The limma R software package (adjusted p 1) was used to screen differentially expressed genes (DEGs)

doi: 10.4103/jcrt.JCRT_862_16 165 GonzalezACasadoJChuecaESalillasSVelazquez-CampoyAEspinosa AngaricaVet al

GHK-Cu increases decorin levels by 302% at 1 nanomolar concentration, which is significant because collagen produced without adequate decorin organization forms disordered, weaker tissue

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