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However, the retrospective design carries inherent limitations

Z44.xxx Used for encounters for fitting and adjustment of external prosthetic devices

It is for established long-term use only

Drug target MR studies have been employed for drug discovery such as PCSK9 inhibition for cognitive function [36], IL-6 inhibition for Alzheimers disease [37], and ACE inhibitors for mental disorders [38]

A limitation of the current study is that it was performed using data from a single academic medical center with limited diversity in terms of patient population