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Factors like poor diet, pollution, smoking, and excessive alcohol consumption contribute to oxidative stress

Newcomer JW, farber NB, Olney JW (2000) NMDA receptor function, memory, and brain aging

This represents a modulatory rather than direct agonist/antagonist profile that distinguishes it from conventional dopaminergic drugs

The dual role of NRF2, as a protector in normal cells and a survival driver in cancer, underscores the need for context-specific modulation, balancing antioxidant support with targeted inhibition to optimize therapeutic outcomes