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PT-141 may provide an alternative or complementary mechanism by addressing central arousal pathways

TaylorMKSullivanDKMorrisJKVidoniEDHoneaRAMahnkenJDet alHigh glycemic diet is related to brain amyloid accumulation over one year in preclinical Alzheimers disease

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Another 12-week RCT assessed the effects of a home-based exercise (resistance band-based exercises, 10 repetitions and five sets, performed 3 days per week) and hypocaloric dietary intervention (1,200 kcal/day) delivered via digital communication applications (e.g., LINE, FaceTime) on muscle mass and function, in older adults (55 years) with overweight or obesity (BMI range, 27 to 35 kg/m 2 ) and knee osteoarthritis [238]

Effect of farnesol on the expression of the SOD1-4 genes in CA and cdr1 cells following 3 h and 18 h exposure to increasing concentrations of farnesol as determined by qRT-PCR analysis