Genistein administration induced Nrf2 enhancement by activation/phosphorylation of keap1, sirt1, MAPK-ERK1/2, PKC, and estrogen receptor in other cells or tissues, such as: hippocampal tissue, hypothalamic paraventricular nucleus, ovary, and Caco-2 cells [131, 135,136,137]
At the same time, it has been hypothesized that autophagy pathways involved in lysophagy in non-erythroid cells, e.g., the p62-mediated pathway [67], might be responsible for the clearance of lysosomes in the erythroid lineage as well [51]
2010;341:c5702
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