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Along with the heterogeneity of the disease and the lack of reliable biomarkers, the problem for developing specific treatments for PD is its multiple pathophysiological mechanisms, many of which are common to the mechanisms of T2DM development, including brain insulin resistance, impaired energy and glucose metabolism, mitochondrial dysfunction, chronic systemic inflammation, neuroinflammation, impaired lysosome function, and oxidative stress [56, 57]

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The clinical trial data gives us precise numbers for what to expect, which is far more useful than vague warnings

When to contact healthcare providers is an essential part of timing discussions

Tsygankova, O., Veretyuk, V., & Ametov, A

Those questions are structural: Does the weight loss continue, plateau, or rebound past 24 weeks