In a retrospective study in Korea, metformin and DPP4i was found to be effective in reducing HbA1c below 7%, with a low incidence of hypoglycemia [92].In tacrolimus-induced SD rat model and nephrotoxicity test, DPP4i and sodiumglucose transporter 2 inhibitors (SGLT2i) reduced blood glucose level and HbA1C level, and increased plasma insulin level and islet size of rats, and improved renal function and reduced interstitial fibrosis and pro-fibrotic cytokines, which providing a theoretical basis for the combination of SGLG2i and DPP4i in the treatment of tacrolimus-induced DM and nephrotoxicity [93]
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Could I try high-dose oral therapy first
Initial results from a randomized controlled trial indicated that it reduced weight and improved diabetic control
Robert Popovian 01:16 Thats right, Connor
Pros: Helps regulate appetite Lowers blood sugar Can result in significant weight loss Cons: Can lead to muscle loss if protein isnt prioritized Often regain weight after stopping Can cause digestive issues, nausea, or vomiting Long-term effects are still being studied Often expensive and not always covered by insurance Can Foods Naturally Promote GLP-1
