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Key findings from SURMOUNT-1 include a mean weight loss of 15.0% at the 5mg dose, 19.5% at the 10mg dose, and 20.9% at the 15mg dose over 72 weeks

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It also forms a protective barrier on the skin, preventing moisture loss and improving the overall texture and appearance of the skin

These effects are linked to alterations in mitochondrial structure, such as changes in membrane phospholipid composition, viscosity, and the structure and function of lipid microdomains, which in turn affect membrane-bound signaling proteins (65, 66)

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Emphysematous cholecystitis [127] is another complication secondary to gas-producing micro-organisms such as the Clostridium welchii