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The good news is there are ways to reduce your exposure to toxins and flush them out of your body

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Toxicity has been demonstrated by extremely high oral doses, but this is uncommon

Studies of glyoxalase 1-linked multidrug resistance reveal glycolysis-derived reactive metabolite, methylglyoxal, is a common contributor in cancer chemotherapy targeting the spliceosome

Lancet Diabetes Endocrinol 8(6):477489 Hocking SL, Markovic TP, Lee CMY (2024) Intensive lifestyle intervention for remission of early type 2 diabetes in primary care in Australia: DiRECT-Aus

The associated shift in the cellular redox state may cause the activation of Nrf2, leading to this additional positive effect on metabolism of high doses of thiamine disulfides, compared to thiamine