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The risk of vitiligo worsening is much higher in individuals with permanent vitiligo, as the disease may be aggravated by exposure to depigmenting agents

In other studies, a decrease in serum cortisol concentration was observed after 60 min of mild exercise, suggesting that such a stimulus may be a factor mitigating the stress response 37

General health status matters for risk tolerance

Botox, on the other hand, is approved for glabellar lines, forehead lines, and crows feet around the eyes