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"Seeing these patterns of lower use of emergency care and lower use of drugs to stop migraines or trying additional drugs to prevent migraines among people taking GLP-1 drugs for other conditions suggests that these therapies may help stabilize the disease burden in ways that we havent fully appreciated yet," Acar said in a statement

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Notably, PPAR has also been reported to activate the AMPK-SIRT1 pathway in human articular cartilage, which not only helps to enhance the energy metabolism and antioxidant capacity of chondrocytes, but also further attenuates inflammatory injury and maintains the functional integrity of cartilage tissue 38

This immune modulation is of research interest for managing inflammation and studying disease progression

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In addition, the latest guidelines classify microglial states into five major phenotypes: homeostatic, DAM-like, HLA/MHC class II, CRM or inflammatory, and interferon (IRM or IFN) clusters [105]