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This is one of the primary reasons researchers are drawn to this combination

Pelkonen, University of Oulu, Finland Reviewed by Risto Juvonen, University of Eastern Finland, Finland

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(See the Supplementary Information (SI) for details.) To elucidate the reasons for the reduced potency at stimulating cAMP accumulation of the non-acylated Tirzepatide after K20 acylation modification, we analyzed the structures of GLP-1R/non-acylated Tirzepatide (PDB: 7VBI) and GIPR/non-acylated Tirzepatide (PDB: 7FIY) complex 20