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doi: 10.3389/fendo.2022.810242 Received 06 November 2021 Accepted 24 January 2022 Published 21 February 2022 Volume 13 - 2022 Edited by Davor Jezek, University of Zagreb, Croatia Reviewed by Gian Maria Busetto, University of Foggia, Italy

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This seems to be consistent with the fact that higher levels of thiomethyl metabolites were observed in PHH than in HRG cells since CYP2E1 activity in primary human hepatocytes is known to be higher than in HRG cells ( 28 )