It is not licensed by the MHRA and UK regulators have publicly warned about it
The candidate has previously advanced through Phase IIa clinical evaluation in obese patients, as well as Phase I single ascending dose (SAD) studies in healthy volunteers and multiple ascending dose (MAD) studies in diabetic patients
Sonia SB, Siddiki MN, Sultana S, Chowdhury IH, Sinha S, Ahmad R, et al
Chest 127 , 515521 (2005)
The PABC moiety functions as a spacer between Val-Cit moiety and the payload, allowing cathepsin B to exhibit its full protease activity to the linker connected to a bulky payload molecule such as doxorubicin (Dubowchik et al., 2002)
A misstep here compromises everything down the line